Sunday, March 22, 2020

March 18, 2020: Bring Research To Market Quickly

"Since these compounds have been used in human patients with a safety track record and shown to be effective against various ailments, we suggest that they should be assessed in human patients suffering from the novel coronavirus disease." 
"Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro"

Manli Wang, Ruiyuan Cao, Gengfu Xiao

Letter to the Editor
Cell Research
4 Feb. 2020
volume 30,
pp. 269–271 
Remdesivir is a possible treatment.

Chloroquine is a possible vaccine. 
Maybe I am wrong about chloroquine being a vaccine. It is being tested as a preventive, and is also used in the UK to treat the illness. (So much for "herd immunity" which they were talking about the other day.)

"even with the ideal containment, the virus's spread may have been inevitable. Testing people who are already extremely sick is an imperfect strategy if people can spread the virus without even feeling bad enough to stay home from work." 
"For a list of Covid-19 clinical trials, search the GlobalData Pharma Intelligence Center Clinical Trials database." 
#1 "Trial GDCT0379047, an interventional planned Phase IV trial, tests the efficacy and safety of a recombinant cytokine gene-derived protein injection combined with Umifenovir (Arbidol), Lopinavir / Litonavir." 
"The study aims to combine the immunostimulatory effects of the cytokine gene-derived protein injection with the anti-viral properties of umifenovir, Lopinavir / Litonavir against Covid-19." 
#2 "Trial GDCT0379500, an interventional ongoing Phase 0 study, aims to test the preventative effects of traditional Chinese medicine (TCM) against Covid-19." 
#3 "trial GDCT0378006 (NCT04246242), an interventional planned Phase IV trial, aims to recruit 500 patients to investigate the use of umifenovir as an add-on to antiviral combination therapy" 
#4 "Trial GDCT0379496 (ChiCTR2000029624), alongside the previously mentioned GDCT0379500, analyzes the use of TCM [Traditional Chinese Medicine]; however, trial GDCT0379496 is studying TCM as a treatment as opposed to a preventative measure. " 
#5 "Trial GDCT0378778 (NCT04257656), an interventional ongoing Phase III trial, is utilizing remdesivir, an anti-viral medication which is in development and indicated for Ebola virus, as a treatment Coronavirus." 
If you look up coronavirus you'll see they have been studying it for many years, and what they're doing in the lab we probably don't want to know. 
The issue is not really coronavirus per se, but rather enhancing our ability to bring research to market quickly (to adapt the human body to emerging pathogens) as well as to achieve social control in the event there is a lag between outbreak and remediation. 
We are going to get coronavirus. Or a version of it. The emphasis needs to be away from this particular bogeyman and toward healthy habits. 
Before she died, my grandmother said: "Be kind to each other." 

By Dr. Dannielle Blumenthal. All opinions are the author's own. Public domain.